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| First Name: | Steven | | Last Name: | Estus | | Title: | Assoc. Prof. | | Advanced Degrees: | Ph.D. | | Affiliation: | Sanders-Brown Center on Aging, University of Kentucky | | Department: | Physiology | | Street Address 1: | 800 S. Limestone | | Street Address 2: | Room 332 | | City: | Lexington | | State/Province: | KY | | Zip/Postal Code: | 40536-0230 | Country/Territory: | U.S.A. | | Email Address: |  |
Disclosure:
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View all comments by Steven Estus
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Polyglutamine Disorders (Huntington's, etc.), Alzheimer Disease, Neuromuscular Disorders (ALS, etc.)
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Molecular and Cell biology, Apoptosis/Cell cycle, Neurobiology, Oxidative Stress, Diagnosis, Signal transduction, Genetics, A-beta PP/A-beta, Animal Models
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Tucker HM, Kihiko M, Caldwell JN, Wright S, Kawarabayashi T, Price D, Walker D, Scheff S, McGillis JP, Rydel RE, Estus S.
The plasmin system is induced by and degrades amyloid-beta aggregates.
J Neurosci. 2000 Jun 1;20(11):3937-46.
PMID: 10818128
Tammariello SP, Quinn MT, Estus S.
NADPH oxidase contributes directly to oxidative stress and apoptosis in nerve growth factor-deprived sympathetic neurons.
J Neurosci. 2000 Jan 1;20(1):RC53.
PMID: 10627630
Estus S, Tucker HM, van Rooyen C, Wright S, Brigham EF, Wogulis M, Rydel RE.
Aggregated amyloid-beta protein induces cortical neuronal apoptosis and concomitant "apoptotic" pattern of gene induction.
J Neurosci. 1997 Oct 15;17(20):7736-45.
PMID: 9315895
Estus S, Zaks WJ, Freeman RS, Gruda M, Bravo R, Johnson EM Jr.
Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis.
J Cell Biol. 1994 Dec;127(6 Pt 1):1717-27.
PMID: 7798322
Golde TE, Estus S, Younkin LH, Selkoe DJ, Younkin SG.
Processing of the amyloid protein precursor to potentially amyloidogenic derivatives.
Science. 1992 Feb 7;255(5045):728-30.
PMID: 1738847
Estus S, Golde TE, Kunishita T, Blades D, Lowery D, Eisen M, Usiak M, Qu XM, Tabira T, Greenberg BD, et al.
Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor.
Science. 1992 Feb 7;255(5045):726-8.
PMID: 1738846
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Events leading to accumulation of amyloid in the AD brain. |
nature cell biology
october 2001 volume 3 issue 10 pp 905 - 912
Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid -peptide
Luigi Puglielli1, Genevieve Konopka3, Eunju Pack-Chung1, Laura A. MacKenzie Ingano1, Oksana Berezovska2, Bradley T. Hyman2, Ta Yuan Chang4, Rudolph E. Tanzi1 and Dora M. Kovacs1 |
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